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Related Experiment Video

Updated: Jul 16, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

Tumor Heterogeneity of RCCs Assessed by mpMRI with Direct Radiological-Histopathological Correlation.

Antonia M Pausch1, Viktoria S Hadnagy2, Toni Rabadi1

  • 1Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.

Diagnostics (Basel, Switzerland)
|July 15, 2026
PubMed
Summary

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Multiparametric MRI (mpMRI) can quantify regional differences within renal cell carcinomas (RCCs). This study found mpMRI parameters correlate with histopathology, potentially improving targeted biopsy and RCC assessment.

Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Renal cell carcinomas (RCCs) exhibit significant intratumoral heterogeneity.
  • Accurate characterization of this heterogeneity is crucial for effective treatment planning.

Purpose of the Study:

  • To evaluate correlations between multiparametric MRI (mpMRI) and histopathological parameters in RCCs.
  • To assess the feasibility of using quantitative mpMRI for targeted biopsy planning by identifying regions of viable tumor.

Main Methods:

  • Prospective pilot study involving patients with renal tumors (≥2 cm) undergoing nephrectomy.
  • Preoperative 3.0T-mpMRI including various sequences (T2, T1, DWI, mapping).
  • Spatially matched regions of interest analyzed for quantitative mpMRI and histopathological parameters (viable tumor, fibrosis, hemorrhage, necrosis).
Keywords:
RCCbiopsyheterogeneitympMRIpathology

More Related Videos

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
07:54

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

Related Experiment Videos

Last Updated: Jul 16, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
07:54

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

Main Results:

  • Analysis of 49 tumor regions across eight patients revealed a mean viable tumor fraction of 80.9%.
  • Viable tumor fraction showed significant inverse correlations with T1 values, diffusion parameters (D, ADC), and signal intensity changes.
  • Delayed and nephrographic phase signal intensity changes were the strongest imaging correlates of viable tumor fraction.

Conclusions:

  • Quantitative mpMRI parameters can effectively capture regional intratumoral heterogeneity in RCCs.
  • These findings support the potential of mpMRI to highlight regions with high viable tumor burden.
  • mpMRI may refine imaging-based assessment and aid in targeted biopsy planning for RCCs.