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Updated: May 18, 2026

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Postnatal mammalian retinal development: quantitative data and general rules.

Heidrun Kuhrt1, Martin Gryga, Hartwig Wolburg

  • 1Paul Flechsig Institute of Brain Research, University of Leipzig, D-04109 Leipzig, Germany.

Progress in Retinal and Eye Research
|September 18, 2012
PubMed
Summary
This summary is machine-generated.

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Mammalian retina development involves significant postnatal expansion, leading to thinner nuclear layers. A physico-mathematical model explains cell movements during this growth.

Area of Science:

  • Developmental biology
  • Ophthalmology
  • Biophysics

Background:

  • Mammalian eye and retina grow post-cytogenesis.
  • Retinal cell numbers stabilize, but retinal surface area doubles.
  • Ocular growth outpaces retinal expansion, altering retinal coverage.

Purpose of the Study:

  • Provide quantitative data on postnatal mammalian retina development.
  • Identify general rules for retinal development at descriptive and mechanistic levels.
  • Model cell translocation during retinal expansion.

Main Methods:

  • Comparative quantitative analysis of postnatal mammalian retina development.
  • Biomechanical analysis of differential retinal expansion.
  • Physico-mathematical modeling of cell movements.

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Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
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Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks
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Published on: August 4, 2018

Related Experiment Videos

Last Updated: May 18, 2026

Organotypic Culture of Adult Rabbit Retina
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Organotypic Culture of Adult Rabbit Retina

Published on: April 29, 2007

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
12:28

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks
08:42

Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks

Published on: August 4, 2018

Main Results:

  • Retinal surface area increases >2x post-cytogenesis.
  • Peripheral retina expands more than central retina due to biomechanical properties.
  • Nuclear layer thickness decreases, requiring cell translocation.

Conclusions:

  • Postnatal retinal expansion involves passive stretching and differential growth.
  • Cellular rearrangements, like photoreceptor somata translocation, accommodate increasing retinal area.
  • A model describes the mechanics of cell movement during retinal development.