Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genetic biomarkers of clinical manifestations in giant cell arteritis define distinct patient subgroups.

Annals of the rheumatic diseases·2026

Same author

Effective Performance of the 2022 American College of Rheumatology/EULAR Classification Criteria for Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Pediatric Patients: An ARChiVe Study.

Arthritis & rheumatology (Hoboken, N.J.)·2026

Same author

Evaluation of the Long-Term Safety of Avacopan in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in the Real World (AvacoStar): Protocol for a Noninterventional Prospective Cohort Study.

JMIR research protocols·2026

Same author

A case of euglycaemic diabetic ketoacidosis in a T2DM patient using Tirzepatide.

Postgraduate medical journal·2025

Same author

Dysregulation of the NLRP3 Inflammasome and Promotion of Disease by IL-1β in a Murine Model of Sandhoff Disease.

Cells·2025

Same author

Long-term surveillance study of rituximab originator treated patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA).

Rheumatology advances in practice·2024

Search research articles

Related Experiment Video

Updated: May 18, 2026

Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography

Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography

Published on: August 11, 2023

Damage assessment in ANCA-associated vasculitis.

Kuljeet Bhamra¹, Raashid Luqmani

¹Nuffield Orthopaedic Centre, Windmill Road, Oxford, OX3 7HE, UK.

Current Rheumatology Reports

|September 18, 2012

Summary

Antineutrophil cytoplasm antibody associated vasculitis is now a chronic condition. Monitoring disease damage, not just activity, is crucial for predicting outcomes and guiding treatment in long-term vasculitis management.

Area of Science:

Rheumatology
Immunology
Internal Medicine

Background:

Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis has shifted from life-threatening to chronic relapsing disease due to immunosuppressive therapy.
Survival rates have improved significantly, with over 70% 5-year survival, making long-term management critical.

Purpose of the Study:

To emphasize the importance of monitoring both active inflammation and chronic damage in ANCA-associated vasculitis.
To highlight the prognostic value of quantifying disease damage using tools like the Vasculitis Damage Index (VDI).

Main Methods:

Review and analysis of existing data on ANCA-associated vasculitis outcomes.
Utilizing the Vasculitis Damage Index (VDI) for damage assessment.

More Related Videos

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Published on: November 24, 2016

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Related Experiment Videos

Last Updated: May 18, 2026

Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography

Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography

Published on: August 11, 2023

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Published on: November 24, 2016

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Main Results:

Over 80% of patients develop chronic damage, which does not respond to immunosuppression.
A VDI score of at least five damage items is associated with a 7- to 11-fold increased mortality risk.
Disease damage is a significant predictor of long-term outcomes.

Conclusions:

Distinguishing disease activity from irreversible damage is vital for appropriate patient management and preventing unnecessary immunosuppression.
Future clinical trials should aim to limit accumulating damage, not solely control disease activity.
The VDI is a valuable tool for predicting mortality and informing management strategies in vasculitis.