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Related Experiment Videos

Factor analysis of false-negative second-look laparotomy.

P Ghatage1, G V Krepart, R Lotocki

  • 1Division of Gynecologic Oncology, University of Manitoba, Winnipeg, Canada.

Gynecologic Oncology
|February 1, 1990
PubMed
Summary
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In ovarian epithelial malignancy patients, a negative second-look laparotomy did not guarantee no recurrence. Serous histology and residual disease were significant predictors of recurrence after negative findings.

Area of Science:

  • Gynecology
  • Oncology

Background:

  • Ovarian epithelial malignancy is a significant cause of cancer-related mortality.
  • Second-look laparotomy is a surgical procedure used to assess disease status after initial treatment.

Purpose of the Study:

  • To evaluate the recurrence rate after a negative second-look laparotomy in ovarian epithelial malignancy.
  • To identify factors predicting recurrence in patients with a negative second-look laparotomy.

Main Methods:

  • Retrospective analysis of 155 patients with ovarian epithelial malignancy.
  • Patients underwent second-look laparotomy between January 1976 and December 1987.
  • Analysis of factors including histology, tumor grade, stage, ascites, and residual disease.

Main Results:

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  • 77 patients (50%) had a negative second-look laparotomy.
  • 15 patients (19.5%) with a negative second-look laparotomy experienced recurrence.
  • Serous histology and presence of residual disease after initial surgery were significant predictors of recurrence.

Conclusions:

  • A negative second-look laparotomy does not exclude the possibility of recurrence in ovarian epithelial malignancy.
  • Serous histology and residual disease are critical factors to consider when assessing recurrence risk.
  • Tumor grade, stage, and ascites were not significant predictors in this cohort.