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Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

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Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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Published on: April 18, 2011

SSRIs: bad to the bone?

Randy A Sansone1, Lori A Sansone

  • 1Departments of Psychiatry and Internal Medicine, Wright State University School of Medicine, Dayton, Ohio, USA. randy.sansone@khnetwork.org

Innovations in Clinical Neuroscience
|September 18, 2012
PubMed
Summary
This summary is machine-generated.

Selective serotonin reuptake inhibitors (SSRIs) may negatively impact bone health, potentially lowering bone mineral density and increasing fracture risk. Caution is advised for patients with osteoporosis or fracture history.

Keywords:
BoneSSRIsfracturesosteoporosisselective serotonin reuptake inhibitorsskeleton

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Area of Science:

  • Pharmacology
  • Bone Biology
  • Clinical Medicine

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed antidepressants.
  • SSRIs generally have a favorable side-effect profile.
  • Potential effects of SSRIs on bone health are not fully understood.

Purpose of the Study:

  • To examine the association between SSRI use and bone health outcomes.
  • To synthesize evidence regarding SSRI effects on bone mineral density and fracture risk.

Main Methods:

  • Systematic review and meta-analysis of 19 studies.
  • Examination of existing literature on SSRI use and bone health.

Main Results:

  • Evidence suggests SSRIs may negatively affect bone mineral density.
  • Increased fracture risk is associated with SSRI use.
  • Risk may be dose- and duration-dependent and influenced by other serotonergic agents.

Conclusions:

  • Serotonin receptors are present on bone cells, suggesting a regulatory role.
  • SSRIs may pose a risk to bone health, particularly in susceptible individuals.
  • Caution is recommended for patients with osteoporosis or prior fractures using SSRIs.