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Circumscribed palmar hypokeratosis: Successful treatment with fluorouracil cream
Michael Wilk1, Bettina G Zelger, Bernhard Zelger
1Dermatohistological Laboratory and Private Practice, Postfach 4145, 90021 Nuernberg, Germany.
Introduction:
The pathogenesis of circumscribed palmar hypokeratosis (CPH) is still controversial, and to date there is no treatment of choice.
Methods:
We report on a patient with CPH responding to treatment with fluorouracil cream.
Results:
The clinical course and histopathological features in our observation point towards the possibility of an underlying squamous cell carcinoma in situ presenting as CPH.
Conclusion:
We suggest that fluorouracil cream treatment should be considered as a therapeutic option in cases of CPH.
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