Related Experiment Video
Updated: May 18, 2026
09:25
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Suboptimal chemotherapy is an adverse prognostic factor in osteosarcoma
Bicheng Yong1, Pingxian Tan, Junqiang Yin
1Musculoskeletal Oncology Department, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
World Journal of Surgical Oncology
|September 19, 2012
Summary
Suboptimal chemotherapy significantly worsens outcomes for osteosarcoma patients. Completing optimal chemotherapy nearly doubles five-year survival rates and reduces relapse and mortality risks.
Area of Science:
- Oncology
- Cancer Research
- Chemotherapy Efficacy
Background:
- Osteosarcoma is a primary bone cancer with variable treatment outcomes.
- Chemotherapy is a cornerstone of osteosarcoma treatment.
- The impact of chemotherapy adherence on prognosis requires further clarification.
Purpose of the Study:
- To investigate the association between chemotherapy adherence and patient prognosis in osteosarcoma.
- To determine if suboptimal chemotherapy compromises survival rates in osteosarcoma patients.
Main Methods:
- Retrospective analysis of 132 osteosarcoma patients treated between 1998 and 2008.
- Data extraction included demographics, clinical characteristics, and survival status.
- Optimal chemotherapy defined as ≥80% of planned dose intensity within planned durations.
Main Results:
- Optimal chemotherapy significantly improved overall survival (P = 0.006).
- Five-year survival was 65.3% for optimal chemotherapy versus 30.8% for suboptimal.
- Suboptimal chemotherapy increased risk of relapse, metastasis, and mortality (HR = 2.512).
Conclusions:
- Chemotherapy adherence is a critical prognostic factor in osteosarcoma.
- Suboptimal chemotherapy negatively impacts patient outcomes.
- Optimizing chemotherapy delivery is essential for improving osteosarcoma prognosis.
Related Concept Videos
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
01:21Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...