Related Experiment Video
Updated: May 18, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
Circular dichroism and anomeric configuration assignment of benzimidazole C-nucleoside analogs
Mohammed A E Sallam1, Omnia G Abdel Hamid, Verena Gossen
1Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21151, Egypt. maesallam@yahoo.com
Abstract:
The circular dichroism of a series of acyclic polyhydroxyalkyl benzimidazole C-nucleoside analogs was correlated with the stereochemistry of the chiral carbon atom α to the benzimidazole base moiety. This correlation was used for the assignment of the anomeric configuration of 2-(β-L-erythrofuranosyl) benzimidazole C-nucleoside analogs without a need to have the other anomer on hand, in a similar manner to the correlation obtained for assignment of the anomeric configuration of triazole C-nucleoside analogs.
Related Concept Videos
Stereoisomerism of Cyclic Compounds
Prochirality
NMR Spectroscopy of Benzene Derivatives
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

