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The clinical and histologic presentation of gingival squamous cell carcinoma: a study of 519 cases
Sarah G Fitzpatrick1, Ashley N Neuman, Donald M Cohen
1Department of Oral Pathology, Case Western Reserve University School of Dental Medicine, Cleveland, OH, USA.
Objectives:
Gingival squamous cell carcinoma (SCCA) often presents with benign features, which may lead to delay in treatment. This study describes the clinical and histologic characteristics of a series of gingival SCCA cases.
Study Design:
A retrospective consecutive case review was performed using the University of Florida College of Dentistry Biopsy service's database, which yielded clinical and histologic information on 519 cases of gingival SCCA.
Results:
The average age of affected patients was 72.3 years. The most common site was the mandibular posterior gingiva. Approximately 72% of lesions were present for >2 months at biopsy. The majority of clinicians considered a malignancy in their differential diagnosis (64%), although 15% considered only reactive lesions. Most of the carcinomas presented as exophytic masses and, histologically, were moderately differentiated.
Conclusions:
Gingival SCCA may present with varied clinical and histologic appearances and should be considered in the differential diagnosis of benign appearing lesions of the gingiva.
