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Altered resting-state functional connectivity after cortical spreading depression in mice
Bing Li1, Fangyuan Zhou, Qingming Luo
1Britton Chance Center of Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan 430074, PR China.
Neuroimage
|September 19, 2012
Summary
Cortical spreading depression (CSD) alters brain network connectivity. This study reveals reduced connectivity between brain hemispheres and increased connectivity within the unaffected hemisphere following CSD events.
Area of Science:
- Neuroscience
- Neuroimaging
- Systems Neuroscience
Background:
- Cortical spreading depression (CSD) is implicated in neurological disorders.
- Previous research indicates CSD affects cerebral cortex structure and function.
- Understanding CSD's impact on cortical functional networks remains limited.
Purpose of the Study:
- To investigate alterations in resting-state functional connectivity (RSFC) of the mouse sensorimotor cortex post-CSD.
- To elucidate the effects of CSD on inter-hemispheric and intra-hemispheric sensorimotor cortex connectivity.
Main Methods:
- Utilized optical intrinsic signal imaging in mice to study CSD.
- Analyzed changes in resting-state functional connectivity (RSFC) of the sensorimotor cortex.
- Employed Amplitude of Low-Frequency Fluctuation (ALFF) analysis to assess neural activity.
Main Results:
- CSD significantly reduced RSFC between ipsilateral and contralateral sensorimotor cortices.
- Increased connectivity was observed within the contralateral somatosensory and motor cortices, and between them.
- ALFF analysis showed increased activity in the ipsilateral cortex and decreased activity in the contralateral cortex post-CSD.
Conclusions:
- CSD significantly alters resting-state functional connectivity in the sensorimotor cortex.
- CSD induces distinct changes in neural activity between ipsilateral and contralateral cortices.
- Functional connectivity analysis provides insights into CSD's impact on cerebral functional networks.
