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Updated: May 18, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
Published on: March 3, 2015
Searching for the Holy Grail; protein-protein interaction analysis and modulation
1Cancer Research Center of Marseille (CRCM, CNRS UMR7258 & Aix-Marseille Université, Marseille, France). xavier.morelli@inserm.fr
Researchers convened to discuss protein-protein interaction analysis and modulation. Key challenges include integrating interactomes for systems biology and modeling signaling networks.
Area of Science:
- Biochemistry
- Systems Biology
- Bioinformatics
Background:
- Protein-protein interactions (PPIs) are fundamental to cellular processes.
- Analyzing and modulating PPIs is crucial for understanding biological networks.
- The integration of interactome data presents significant challenges.
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