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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

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Polymorphic haplotypes of CRELD1 differentially predispose Down syndrome and euploids individuals to atrioventricular

Priyanka Ghosh1, Pranami Bhaumik, Sujoy Ghosh

  • 1Human Genetics Research Unit, School of Biotechnology and Biological Sciences, West Bengal University of Technology, Kolkata, West Bengal, India.

American Journal of Medical Genetics. Part A
|September 19, 2012
PubMed

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Nondisjunction

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Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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