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Angiosarcoma of the scalp associated with Xeroderma pigmentosum
Shilpi Sharma1, Anuja D Deshmukh, Munita M Bal
1Department of Head and Neck Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
Abstract:
Xeroderma pigmentosum (XP) is a rare autosomal recessive genodermatosis associated with hypersensitivity to ultraviolet light due to defects in Deoxyribonucleic acid (DNA) repair. These patients have more than a 1000-fold increased risk of developing skin cancers. Although multiple cutaneous malignancies are common, the simultaneous occurrence of angiosarcoma and basal cell carcinoma is a rare phenomenon. We report a case of a 25-year-old male with XP with angiosarcoma scalp and basal cell carcinoma of face and occiput and discuss the treatment of this aggressive neoplasm with a review of the literature pertaining to it.
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