Lateralization of motor control in the human nervous system: genetics of mirror movements

Mirror movements (MM) are a peculiar motor defect in humans where the intended unilateral movement of a body part results in involuntary movement of the same body part on the opposite side. This loss in the lateralization of motor control can be caused by genetic mutations that result in an aberrant projection of the corticospinal tract. However, recent evidence suggests that the same genes controlling corticospinal tract development also play roles in the development of other circuits involved in motor control, including local spinal circuits and the corpus callosum. These recent studies in humans and mouse models of MM will be discussed to provide an overview of the basis of MM and the molecular mechanisms underlying the lateralization of motor control.