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Updated: May 18, 2026
09:22
Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
Published on: May 12, 2020
New treatments for bacterial keratitis
Raymond L M Wong1, R A Gangwani, Lester W H Yu
1Eye Institute, The University of Hong Kong, Room 301, Level 3, Block B, 100 Cyberport Road, Cyberport 4, Hong Kong.
Journal of Ophthalmology
|September 20, 2012
Summary
Newer treatments like fourth-generation fluoroquinolones and corneal collagen cross-linking offer effective alternatives for bacterial keratitis, addressing antibiotic resistance and improving healing.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Background:
- Bacterial keratitis treatment traditionally relies on broad-spectrum antibiotics.
- Emerging bacterial resistance necessitates novel antimicrobial agents and therapeutic strategies.
Purpose of the Study:
- To review and synthesize recent advancements in treating bacterial keratitis.
- To evaluate the efficacy of novel therapeutic options beyond traditional antibiotics.
Main Methods:
- Comprehensive PubMed literature search up to April 2012.
- Selection of large-scale studies and recent publications using keywords like 'infectious keratitis' and 'collagen cross-linking'.
Main Results:
- Fourth-generation fluoroquinolones demonstrate potency comparable to fortified antibiotics against common bacterial keratitis pathogens.
- Corneal collagen cross-linking shows promise in enhancing infectious corneal ulcer healing, particularly in resistant cases or as adjunctive therapy.
Conclusions:
- Fourth-generation fluoroquinolones represent a viable alternative to standard fortified topical antibiotic regimens for bacterial keratitis.
- Corneal collagen cross-linking is a potential consideration for treatment-resistant bacterial keratitis or as an adjunct to antibiotic therapy.
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