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Related Concept Videos

Multicompartment Models: Overview01:14

Multicompartment Models: Overview

Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
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Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
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Related Experiment Video

Updated: May 18, 2026

Reconfigurable Microfluidic Channel with Pin-discretized Sidewalls
10:39

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Published on: April 12, 2018

Spontaneous shape reconfigurations in multicompartmental microcylinders.

Kyung Jin Lee1, Jaewon Yoon, Sahar Rahmani

  • 1Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Proceedings of the National Academy of Sciences of the United States of America
|September 21, 2012
PubMed
Summary

Researchers developed reconfigurable microparticles using unique architectures, not complex materials. These multicompartmental microcylinders can actively change shape in response to stimuli like ultrasound or solvents.

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Area of Science:

  • Materials Science
  • Microfluidics
  • Soft Matter Physics

Background:

  • Natural particles like cells and spores exhibit adaptive shape changes in response to environmental cues.
  • Synthetic reconfigurable microparticles are challenging to create, with limited examples available.
  • Existing approaches often rely on sophisticated materials like shape-memory polymers.

Purpose of the Study:

  • To demonstrate a novel, generic approach for creating dynamically reconfigurable synthetic microparticles.
  • To utilize unique anisotropic particle architectures for reconfigurability, avoiding complex material synthesis.
  • To explore the potential of these microparticles in adaptive materials and applications.

Main Methods:

  • Electrohydrodynamic cojetting was employed to fabricate multicompartmental microcylinders with specific anisotropic architectures.
  • Conventional polymers were used, highlighting the architectural rather than material basis for reconfigurability.
  • External stimuli, including ultrasound and specific solvents, were applied to induce reconfiguration.

Main Results:

  • Multicompartmental microcylinders demonstrated active reconfiguration, including shape-shifting, reversible switching, and three-way toggling.
  • Reconfiguration was driven by interfacial stresses generated upon exposure to external stimuli.
  • The process proved versatile regarding material selection and processing capabilities.

Conclusions:

  • A generic method for creating dynamically reconfigurable microparticles based on architecture has been established.
  • This approach offers a pathway to novel adaptive materials with potential applications in sensors, microactuators, and drug delivery.
  • The electrohydrodynamic cojetting technique provides a versatile platform for designing such advanced microparticle systems.