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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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hTERT-based therapy: a universal anticancer approach (Review).

Mu-Han Lü1, Zhong-Li Liao, Xiao-Yan Zhao

  • 1Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China.

Oncology Reports
|September 21, 2012
PubMed
Summary

Human telomerase reverse transcriptase (hTERT) is a key protein in cancer development and maintenance. Targeting hTERT offers promising therapeutic strategies for various cancers, with ongoing research addressing current challenges.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Human telomerase reverse transcriptase (hTERT) is crucial for cell proliferation, immortalization, metastasis, and stemness in most cancers.
  • hTERT exhibits minimal expression in normal somatic cells, making it a specific cancer target.

Purpose of the Study:

  • To review current knowledge on hTERT's role in various cancers.
  • To discuss hTERT-based therapies and their potential in cancer eradication.
  • To identify challenges and opportunities in developing hTERT-targeted cancer treatments.

Main Methods:

  • Literature review of hTERT's function in cancer.
  • Analysis of current hTERT-based therapeutic approaches (immunotherapy, suicide gene therapy, small-molecule therapy).
  • Discussion of obstacles and future directions in hTERT-targeted therapy development.

Main Results:

  • hTERT is implicated in multiple hallmarks of cancer.
  • Various hTERT-based therapies are emerging as critical and specific treatment options.
  • Significant progress has been made in understanding hTERT's therapeutic potential.

Conclusions:

  • hTERT is a validated target for novel cancer therapies.
  • Further research is needed to overcome hurdles and optimize hTERT-based treatment strategies.
  • Targeting hTERT holds promise for eradicating diverse cancer types.