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Updated: May 18, 2026

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye
Published on: January 14, 2021
A review of genome-wide approaches to study the genetic basis for spermatogenic defects
Kenneth I Aston1, Donald F Conrad
1Department of Surgery, Division of Urology, Andrology & IVF Laboratories, University of Utah School of Medicine, Salt Lake City, UT, USA, Kenneth.aston@hsc.utah.edu.
Abstract:
Rapidly advancing tools for genetic analysis on a genome-wide scale have been instrumental in identifying the genetic bases for many complex diseases. About half of male infertility cases are of unknown etiology in spite of tremendous efforts to characterize the genetic basis for the disorder. Advancing our understanding of the genetic basis for male infertility will require the application of established and emerging genomic tools. This chapter introduces many of the tools available for genetic studies on a genome-wide scale along with principles of study design and data analysis.
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