Related Experiment Video
Updated: May 18, 2026

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
Published on: November 21, 2023
Air leaks localized with lung ventilation SPECT.
Gaetane Ceulemans1, Liesbeth De Meirleir, Marleen Keyaerts
1Departments of Nuclear Medicine, UZ Brussel, Laarbeeklaan, Brussels, Belgium. ceulemansgaetane@yahoo.com
Persistent air leaks after lung surgery for spontaneous secondary pneumothorax can be challenging. Fused imaging identified unexpected thoracic wall emphysema as a contributing factor, leading to successful conservative management.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Nuclear Medicine
Background:
- Recurrent spontaneous secondary pneumothorax in patients with severe chronic obstructive pulmonary disease (COPD) poses significant management challenges.
- Standard surgical interventions like pleurodesis and bullectomy may not always resolve persistent air leaks.
Observation:
- A 61-year-old male with severe COPD experienced recurrent right-sided pneumothorax.
- Despite thoracoscopic abrasion, bullectomy, and pleural decortication, a significant air leak persisted.
- Quantitative ventilation/perfusion SPECT and high-resolution CT fused with Tc Technegas imaging were employed to localize the air leak.
Findings:
- The fused imaging accurately identified the air leak originating not only from a bleb in the right upper lobe but also from subcutaneous emphysema in the thoracic wall.
- This unexpected finding in the thoracic wall was crucial for guiding subsequent management.
Implications:
- Integrated imaging techniques can precisely localize complex air leaks in the thorax, even when they extend beyond the lung parenchyma.
- Identifying thoracic wall involvement in air leaks can facilitate a shift towards conservative management, potentially avoiding more extensive surgery.
- This case highlights the value of advanced imaging in optimizing treatment strategies for challenging respiratory conditions like pneumothorax in COPD patients.
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02:09Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
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