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Updated: May 18, 2026
09:08
From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library
Susanna Kushnir1, Uschi Sundermann, Samir Yahiaoui
1Fakultät für Chemie, Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Strasse 6, 44221 Dortmund, Germany.
Angewandte Chemie (International Ed. in English)
|September 22, 2012
Abstract:
Not in the public domain: Site-directed mutagenesis of megasynthases was the key to the generation of a library of polyketides in bacteria. Redox derivatizations are used to change the bioactivity profile of the compounds.
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01:16In-vitro Mutagenesis
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