Related Experiment Video

Updated: May 18, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
06:44

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

Functional p53 determines docetaxel sensitivity in prostate cancer cells

Chengfei Liu1, Yezi Zhu, Wei Lou

  • 1Department of Urology, University of California at Davis, Sacramento, California 95817, USA.

The Prostate
|September 22, 2012
PubMed
Summary

Docetaxel resistance in prostate cancer is linked to p53 status. Functional p53 enhances docetaxel sensitivity and apoptosis, while its absence reduces sensitivity in castration-resistant prostate cancer (CRPC) models.

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