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Updated: May 18, 2026

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
Published on: August 24, 2012
[Pharmacological intervention of conditioned fear and its extinction]
Renzhi Huang1, Zexuan Li, Huan Chen
1Department of Teaching Science, Hunan First Normal College, Changsha, China.
Abstract:
Conditioned fear and its abnormal extinction are involved in the psychopathology of anxiety disorders, such as posttraumatic stress disorder (PTSD). Cognitive enhancing agents have been demonstrated to alter fear extinction in many animal research literatures. The present review has examined the pharmacological role of gamma-aminobutyric acid (GABA), glutamatergic, cholinergic, adrenergic, dopaminergic, and cannabinoid as well as compounds able to alter the epigenetic and neurotrophic mechanism in fear extinction, highlighting great hope for the future treatment of anxiety disorders with new agents based on the fear extinction.
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