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Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Related Experiment Video

Updated: May 18, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression.

Stefan Schneeberger1, Vijay S Gorantla, Gerald Brandacher

  • 1Department of Plastic and Reconstructive Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Annals of Surgery
|September 25, 2012
PubMed
Summary
This summary is machine-generated.

This study shows a novel bone marrow cell protocol safely reduces immunosuppression for hand transplant patients, improving outcomes with low-dose tacrolimus monotherapy.

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Published on: September 18, 2011

Area of Science:

  • Immunology
  • Transplantation Surgery
  • Regenerative Medicine

Background:

  • Reconstructive transplantation is limited by immunosuppression risks.
  • A novel donor bone marrow (BM) cell protocol was developed to minimize immunosuppression in upper-extremity transplantation.
  • The
  • Pittsburgh protocol
  • aims to improve the risk-benefit balance of hand and forearm transplants.

Observation:

  • Five patients underwent upper-extremity transplantation (hand/forearm) between 2009-2010.
  • Induction involved alemtuzumab and methylprednisolone, followed by tacrolimus monotherapy.
  • Donor BM cells were infused on day 14 post-transplant.

Findings:

  • Patients were maintained on low-dose tacrolimus monotherapy (4-12 ng/mL).
  • Infrequent, reversible skin rejections and no infections were observed.
  • Sustained functional improvements (motor, sensory) and patent vessels were noted, with minimal side effects.

Implications:

  • The BM cell-based protocol is safe and well-tolerated for upper-extremity transplantation.
  • This approach allows for reduced immunosuppression, specifically low-dose tacrolimus monotherapy.
  • This strategy may enhance the feasibility and safety of reconstructive transplantation procedures.