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Plastic surgery in pseudoxanthoma elasticum: experience in nine patients
D L Viljoen1, C Bloch, P Beighton
1Department of Human Genetics, University of Cape Town Medical School.
Plastic and Reconstructive Surgery
|February 1, 1990
Summary
Cosmetic surgery for pseudoxanthoma elasticum (PXE) showed favorable outcomes with moderate skin improvement over 15 years. Some patients experienced delayed healing due to calcium particle extrusion.
Area of Science:
- Dermatology
- Plastic Surgery
- Medical Genetics
Background:
- Pseudoxanthoma elasticum (PXE) is a rare genetic disorder affecting elastic tissues.
- Severe cutaneous stigmata in PXE can significantly impact patients' quality of life.
- Surgical interventions are sometimes considered for managing cosmetic concerns in PXE.
Purpose of the Study:
- To evaluate the efficacy and safety of cosmetic surgery for PXE-related skin manifestations.
- To assess the long-term outcomes and potential complications of surgical correction in PXE patients.
Main Methods:
- Nine female patients with PXE underwent surgical procedures for skin correction.
- Follow-up periods extended up to 15 years post-surgery.
- Clinical outcomes, including aesthetic results and complications, were monitored.
Main Results:
- Generally favorable cosmetic outcomes were observed.
- Moderate regression of skin stigmata was noted during the follow-up period.
- While most patients tolerated surgery well, two experienced delayed healing due to calcium particle extrusion, leading to scarring. Tissue friability and keloid formation were noted in a minority.
Conclusions:
- Cosmetic surgery can offer satisfactory results for PXE skin stigmata.
- Potential complications like delayed healing due to calcification extrusion should be considered.
- Careful patient selection and surgical technique are important for managing PXE patients.