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Related Experiment Video

Updated: May 18, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Systemic lupus erythematosus developing immediately after necrotizing fasciitis.

S Santoro¹, C Cortelazzi, M Santini

¹Section of Dermatology, Department of Surgical Sciences, Parma University, Parma, Italy.

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia

|September 26, 2012

Summary

Necrotizing fasciitis (NF), a severe bacterial infection, can precede the development of Systemic Lupus Erythematosus (SLE), a serious autoimmune disease. This case highlights a potential link between NF and subsequent SLE onset.

Related Experiment Videos

Last Updated: May 18, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Area of Science:

Immunology
Infectious Diseases
Rheumatology

Background:

Necrotizing fasciitis (NF) is a rapidly progressing bacterial infection of subcutaneous tissue and fascia.
Systemic lupus erythematosus (SLE) is a severe autoimmune disease affecting multiple organ systems.
The association between NF and the subsequent development of SLE has not been previously reported in medical literature.

Observation:

A case study involving a patient who developed insect-bite-induced NF.
The patient subsequently experienced the immediate onset of SLE following the NF diagnosis.
This represents a novel observation of a potential post-infectious autoimmune sequela.

Findings:

The presented case is the first reported instance of SLE developing immediately after NF.
This suggests a potential causal or triggering relationship between NF and SLE.
The findings highlight a possible pathway from severe infection to autoimmune disease.

Implications:

This case provides early evidence for post-infectious autoimmunity following NF.
Clinicians should exercise caution and consider monitoring for autoimmune conditions in NF patients.
Further research is warranted to understand the mechanisms linking NF and SLE development.