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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Cross-reactivity00:42

Cross-reactivity

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Protease Activity-Independent, Th Cell-Dependent Airway IL-33 Release Drives Eosinophilia in Mice Presensitized to Papain via SDS-Treated Skin.

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Antigen Protease Activity on Intact or Tape-Stripped Skin Induces Acute Itch and T Helper Sensitization Leading to Airway Eosinophilia in Mice.

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[ALLERGEN PROTEASE ACTIVITY PROMOTES INFLAMMATION AND SENSITIZATION].

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Antigen Protease Activity with a Detergent Induces Severe Skin Inflammation with Itch and Robust T Helper 17/T Helper 22 Differentiation in Mice.

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Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice.

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Epicutaneous challenge with protease allergen requires its protease activity to recall T<sub>H</sub>2 and T<sub>H</sub>17/T<sub>H</sub>22 responses in mice pre-sensitized via distant skin.

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Related Experiment Video

Updated: May 18, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

[Three faces of allergen]

Toshiro Takai1

  • 1Atopy Allergy Research Center, Juntendo University Graduate School of Medicine. t-takai@juntendo.ac.jp

Arerugi = [Allergy]
|September 26, 2012
PubMed
Summary

No abstract available in PubMed .

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