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Preparation of pixantrone/poly(γ-glutamic acid) nanoparticles through complex self-assembly for oral chemotherapy
Lili Meng1, Bing Ji, Wei Huang
1School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Abstract:
A facile and green approach is reported to construct pixantrone/poly(γ-glutamic acid) nanoparticles (PIX/γ-PGA NPs) as an oral drug delivery system through the complex self-assembly of polyelectrolyte γ-PGA and the anticancer drug pixantrone dimaleate (PDM). The complex self-assembly behavior is investigated in detail. The results demonstrate that PDM can interact with γ-PGA to conveniently form NPs and the size of NPs can be controlled by adjusting the solution volume ratio of PDM to γ-PGA. These NPs illustrate their pH-dependent release behavior, efficient cellular uptake and enhanced drug efficacy through an in vitro release study, flow cytometry, CLSM analysis and the MTT assay. In summary, PIX/γ-PGA NPs may serve as a promising oral drug delivery system for cancer therapy.
