Primary and secondary amputation in critical limb ischemia patients: different aspects

The TASC II working group reports on primary amputation incidence rates vary between 12 and 50 per 100,000 per year. The primary amputation rate does not only depend on co-morbidities like diabetes and PAD, but also on local factors like the regional availability of vascular surgeons and interventional radiologists and their case load. Further-more, several studies could show that increasing revascularisation rates have drastically reduced amputation rates in the US, with a 50% decrease in amputation rates during a 10 year study period and a corresponding increase in surgical and endovascular revascularisation rates. An analysis of national and state US databases confirmed a drop in major amputations and open surgical revascularisations, in favour of an increase in endovascular interventions. The same study observed an increase in minor amputations during the same period. However, it remains unclear whether this trend is a consequence of the increased usage of endovascular procedures in high-risk patients who are unfit for open surgery or of earlier endovascular intervention in less critical lesions. This review gives an overview of the incidence, indication, amputation-level finding and outcome of major amputations performed in critical limb ischemia (CLI) patients.