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Updated: May 18, 2026

Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization

Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization

Published on: October 6, 2019

Targeting IRF4 in autoimmune diseases.

Wang-Dong Xu¹, Hai-Feng Pan, Dong-Qing Ye

¹Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China.

Autoimmunity Reviews

|September 27, 2012

Summary

Interferon regulatory factor 4 (IRF4) plays a key role in immune cell development and function. This review highlights IRF4's pathological roles in autoimmune diseases and its therapeutic potential.

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Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization

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Published on: October 6, 2019

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Area of Science:

Immunology
Molecular Biology
Autoimmunity

Background:

Interferon regulatory factor 4 (IRF4) is a transcription factor crucial for immune cell development and function.
IRF4 is expressed in various immune cells, including T helper cells, regulatory T cells, B cells, and dendritic cells.
These immune cells are implicated in the pathogenesis of several autoimmune diseases.

Purpose of the Study:

To review the recent advances in understanding the pathological roles of IRF4 in autoimmunity.
To discuss the therapeutic significance of targeting IRF4 in autoimmune diseases.

Main Methods:

Literature review of recent findings on IRF4 in autoimmunity.
Synthesis of information on IRF4's role in immune cell function and disease pathogenesis.

Main Results:

IRF4 is essential for the development and function of key immune cells involved in autoimmune diseases.
Dysregulation of IRF4 contributes to the initiation and progression of autoimmune conditions.
Specific autoimmune diseases discussed include systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, and type I diabetes.

Conclusions:

IRF4 plays a significant pathological role in various autoimmune diseases.
Targeting IRF4 presents a potential therapeutic strategy for managing autoimmune disorders.