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[Pathophysiological role of tissue renin-angiotensin-aldosterone system (RAAS) in human atherosclerosis]

Kensuke Fukui1, Hiroyuki Yamada, Hiroaki Matsubara

  • 1Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 28, 2012
PubMed

Insights

The renin-angiotensin-aldosterone system (RAAS) is crucial in atherosclerosis. Blocking RAAS offers cardiovascular benefits beyond blood pressure reduction, but its plaque-stabilizing mechanisms require further study.

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Pathophysiology

Context:

  • The renin-angiotensin-aldosterone system (RAAS) is implicated in atherosclerosis development.
  • RAAS blockade shows cardiovascular benefits, including improved endothelial function and reduced mortality/morbidity.
  • Mechanisms for plaque stabilization and rupture inhibition by RAAS blockade are not fully understood.

Purpose:

  • To summarize tissue RAAS expression in human atherosclerotic lesions.
  • To assess the therapeutic relevance of RAAS in preventing atherosclerotic cardiovascular diseases.

Summary:

  • RAAS plays a significant role in atherosclerosis pathogenesis.
  • RAAS blockade provides cardiovascular protection independent of blood pressure effects.
  • Further research is needed to elucidate RAAS's role in plaque stabilization and acute coronary syndrome prevention.

Impact:

  • Understanding tissue RAAS expression can guide therapeutic strategies for atherosclerotic cardiovascular diseases.
  • Elucidating RAAS mechanisms may lead to novel treatments for vulnerable plaque and acute coronary syndrome.
  • This review highlights the therapeutic potential of targeting RAAS in cardiovascular disease prevention.

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