Related Experiment Video
Updated: May 18, 2026

Determination of Cardiac Output in a Porcine Model for Ex Vivo Pulmonary Perfusion
Published on: June 28, 2024
[Comparison of continuous cardiac output measurement methods: non-invasive estimated CCO using pulse wave transit
Masato Tsutsui1, Takashige Yamada, Yoshihiro Sugo
1Department of Anesthesiology, National Defense Medical College, Tokorozawa 359-0042.
Background:
esCCO (estimated continuous cardiac output, Nihon Kohden, esCCO) is a new cardiac output measurement system which uses pulse wave transit time to calculate cardiac output continuously and non-invasively. One of the most commonly used methods to monitor cardiac output is continuous cardiac output CCO (Edwards Lifesciences) which has an accuracy equivalent to that of thermodilution method.
Methods:
We compared esCCO to CCO in 67 operating room patients and 128 intensive care unit patients. CCO and esCCO were measured simultaneously in patients with a pulmonary artery catheter inserted after admission to the operating room or intensive care unit.
Results:
CCO and esCCO showed a high correlation with a correlation coefficient of 0.84 in 496 total data points, and 95% limits of agreement between these two methods were -2.49 to 2.35 l x min(-1).
Conclusions:
This result suggests that esCCO could be used to measure cardiac output accurately and non-invasively in different cases.
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