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Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
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[Correction of bioenergetic processes in small intestine during experimental widespread purulent peritonitis]

V A Kosinets

    Eksperimental'Naia I Klinicheskaia Farmakologiia
    |September 28, 2012
    PubMed

    Insights

    Widespread purulent peritonitis (WPP) impairs mitochondrial function in the small intestine. Cytoflavin treatment effectively restored mitochondrial activity, exceeding normal levels and aiding recovery from enteric insufficiency.

    Area of Science:

    • Mitochondrial physiology
    • Gastroenterology
    • Experimental surgery

    Background:

    • Mitochondrial dysfunction is a key factor in organ damage during sepsis.
    • Small intestine integrity is crucial for preventing systemic complications in peritonitis.

    Purpose of the Study:

    • To investigate the impact of widespread purulent peritonitis (WPP) on mitochondrial function in the small intestine's muscular coat (MCSI).
    • To compare the efficacy of metabolic drugs cytoflavin and neoton in mitigating WPP-induced mitochondrial damage.
    • To evaluate the potential of cytoflavin in normalizing biological oxidation and resolving enteric insufficiency.

    Main Methods:

    • Experimental induction of WPP in 55 male chinchilla rabbits.
    • Assessment of mitochondrial functional activity in MCSI samples.
    • Comparative analysis of cytoflavin and neoton administration post-WPP.

    Main Results:

    • WPP significantly decreased the functional activity of MCSI mitochondria.
    • Cytoflavin demonstrated superior efficacy compared to neoton.
    • Cytoflavin administration led to mitochondrial indices exceeding those of intact animals by day five post-surgery.

    Conclusions:

    • WPP severely compromises mitochondrial function in the small intestine.
    • Cytoflavin is an effective therapeutic agent for WPP, promoting mitochondrial recovery.
    • The use of cytoflavin in complex WPP treatment is recommended for restoring metabolic processes and addressing enteric insufficiency.

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