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Topical cidofovir for refractory verrucae in children
Monique Gupta1, Susan J Bayliss, David R Berk
1Division of Dermatology, Department of Internal Medicine, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri 63110, USA.
Pediatric Dermatology
|September 28, 2012
Summary
Topical cidofovir shows limited success in treating children's warts. This study found only 25% complete clearance, suggesting lower concentrations and less frequent application may reduce efficacy for refractory warts.
Area of Science:
- Dermatology
- Pediatrics
- Virology
Background:
- Warts are common pediatric skin infections.
- Refractory warts pose treatment challenges, especially in immunocompromised children.
- Topical cidofovir, an antiviral nucleotide analogue, has shown promise for difficult-to-treat warts.
Purpose of the Study:
- To evaluate the efficacy of topical cidofovir in treating refractory warts in children.
- To assess outcomes of a specific compounded formulation and application regimen.
Main Methods:
- Retrospective institutional review of 12 pediatric patients.
- Treatment involved 1% to 3% topical cidofovir compounded in cream.
- Application ranged from every other day to daily.
Main Results:
- Complete clearance of warts was observed in 3 patients (25%).
- Partial clearance was achieved in 4 patients (33%).
- Overall efficacy was lower than anticipated, potentially due to lower concentration and dosing frequency.
Conclusions:
- Topical cidofovir demonstrated limited efficacy in this series of refractory pediatric warts.
- Lower concentrations and less frequent application may impact treatment success.
- Further research is needed to optimize topical cidofovir's use, including dosing and safety profiles.
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