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Related Experiment Video

Updated: May 18, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Compact laser Doppler choroidal flowmeter.

M H Geiser, U Diermann, C E Riva

    Journal of Biomedical Optics
    |September 28, 2012
    PubMed
    Summary
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    A new compact instrument measures blood flow parameters in the human eye's foveal region using laser Doppler velocimetry. This device offers reproducible measurements for ocular blood flow research.

    Area of Science:

    • Ophthalmology
    • Biomedical Optics
    • Medical Instrumentation

    Background:

    • Accurate measurement of ocular blood flow is crucial for understanding and diagnosing various eye conditions.
    • Existing methods for assessing foveal blood flow can be invasive or lack precision.

    Purpose of the Study:

    • To introduce and validate a novel compact instrument for measuring laser Doppler flow parameters in the human foveal choroidal vascular system.
    • To assess the reproducibility and sensitivity of the new device for ocular blood flow measurements.

    Main Methods:

    • Development of a compact instrument utilizing confocality for laser light delivery and heterodyne detection.
    • Measurement of blood velocity, volume, and flow in the foveal region of 21 normal volunteers using a 785 nm laser (90 μW incident power).

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  • Determination of intrasubject reproducibility and minimum detectable changes in flow parameters.

    • Main Results:

    • The instrument successfully measured laser Doppler flow parameters (velocity, volume, flow) in the foveal region.
    • High intrasubject reproducibility and statistically significant detectable changes in flow parameters were determined.
    • Linear correlations between flow parameters in the right and left eyes were established.

    Conclusions:

    • The described compact instrument provides a non-invasive and reproducible method for assessing foveal choroidal blood flow.
    • This technology holds potential for clinical applications in diagnosing and monitoring eye diseases related to blood flow abnormalities.