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Choroidal perfusion abnormality with age-related Bruch's membrane change
D Pauleikhoff1, J C Chen, I H Chisholm
1Department of Clinical Ophthalmology, Institute of Ophthalmology, London, England.
American Journal of Ophthalmology
|February 15, 1990
Summary
A prolonged choroidal filling phase observed during fluorescein angiography may signal diffuse thickening of Bruch
Area of Science:
- Ophthalmology
- Retinal Imaging
- Choroidal Physiology
Background:
- Sorsby's fundus dystrophy is linked to changes in Bruch's membrane.
- Choroidal filling dynamics are crucial for retinal health.
Purpose of the Study:
- To investigate the relationship between prolonged choroidal filling and diffuse thickening of Bruch's membrane.
- To determine if fluorescein angiography can detect early signs of Bruch's membrane changes.
Main Methods:
- Analysis of fluorescein angiography transit photographs.
- Study included 100 eyes from 100 consecutive patients with age-related changes.
- Evaluated choroidal filling phases during initial dye transit.
Main Results:
- 26 out of 100 eyes exhibited a prolonged choroidal filling phase.
- This finding was observed in patients with age-related changes at the level of Bruch's membrane.
Conclusions:
- Prolonged choroidal filling during fluorescein angiography may be a clinical indicator of diffuse Bruch's membrane thickening.
- Suggests a causal relationship between observed angiography findings and Bruch's membrane pathology.