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Mindfulness-based cognitive therapy for multiple chemical sensitivity: a study protocol for a randomized controlled

Christian Riise Hauge¹, Peter Jens E Bonde, Alice Rasmussen

¹The Danish Research Centre for Chemical Sensitivities, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Ledreborg Alle 40, 2th, Gentofte 2820, Copenhagen, Denmark. christian.riise.hauge@regionh.dk

|September 29, 2012

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Mindfulness-Based Cognitive Therapy (MBCT) may effectively reduce the impact of Multiple Chemical Sensitivity (MCS) and associated distress. This randomized controlled trial assesses MBCT

Area of Science:

Psychiatry
Environmental Health

Background:

Multiple Chemical Sensitivity (MCS) involves self-reported symptoms across multiple organ systems triggered by low-level chemical exposures.
The pathophysiology of MCS remains unknown, leading individuals to adopt avoidance strategies that severely impact daily life.
There is a significant need for interventions to alleviate MCS symptoms, reduce psychological distress, and improve quality of life.

Purpose of the Study:

To evaluate the effectiveness of a Mindfulness-Based Cognitive Therapy (MBCT) program for individuals with Multiple Chemical Sensitivity (MCS).
To assess the impact of MBCT on the daily lives of MCS patients, including symptom reduction and psychological distress alleviation.

Main Methods:

A randomized controlled trial (RCT) comparing MBCT with treatment as usual (TAU).

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MBCT intervention: 8 weekly 2.5-hour sessions with 45 minutes of daily home practice.

Data collection via questionnaires at baseline, post-treatment, and 6/12-month follow-ups, assessing primary and secondary outcomes including quality of life and work ability.

Main Results:

The study will measure the impact of MCS on participants' lives as the primary outcome.
Secondary outcomes include physical symptoms, psychological distress, perceived stress, illness perceptions, quality of life, and work ability.
Mediation analysis will explore the role of mindfulness, self-compassion, perceived stress, and rumination in MBCT's effects.

Conclusions:

This clinical trial is expected to provide crucial data on the efficacy of MBCT in managing Multiple Chemical Sensitivity (MCS).
Findings will inform the development of evidence-based interventions for MCS patients, potentially improving their overall well-being and daily functioning.