Related Experiment Video
Updated: May 18, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
microRNA biogenesis pathway as a therapeutic target for human disease and cancer
Francesca De Santa1, Ilaria Iosue, Alberto Del Rio
1Department of Medico- Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, 04100, Italy. francesco.fazi@uniroma1.it
Abstract:
The deregulation of microRNAs expression and activity is frequently observed in a wide variety of human pathologies including cancer. Accordingly, growing evidence indicates that the targeting of microRNAs biogenesis and pathways is emerging as a central tool for the development of novel RNA-based drugs and therapies to defeat diseases in humans. In this review we describe the various strategies that can be used to target microRNAs and specific RNA-binding proteins, involved in the regulation of their production, localization, stability and activity, in human cancer and cardiovascular diseases. We also focus on the efforts that are currently made to enhance the potency and stability of these therapeutic agents and their delivery to modulate in vivo microRNAs pathways. Finally, we present structural data on proteins that belong to the microRNA pathway for small molecules-based target therapy design.
Related Concept Videos
MicroRNAs
MicroRNAs
MicroRNAs
Microorganisms in Medicine and Therapeutics
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

