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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

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Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
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Published on: May 4, 2011

Associations between serotonin transporter polymorphisms and cognitive processing applying the Emo 1-back task.

Rune Jonassen1, Kari B Foss Haug, Tor Endestad

  • 1Department of Psychology, Centre for the Study of Human Cognition, 0317 Oslo, Norway. rune.jonassen@psykologi.uio.no

Cognition & Emotion
|September 29, 2012
PubMed
Summary
This summary is machine-generated.

The short allele of the serotonin transporter gene (5-HTTLPR) is linked to difficulties processing sad or fearful emotional faces. This genetic variation may impact how individuals process emotions.

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Last Updated: May 18, 2026

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychology

Background:

  • Reduced serotonin transporter (5-HTT) expression is linked to brain function and major depression.
  • Allelic variations in the serotonin transporter gene (SLC6A4) may influence emotional processing.

Purpose of the Study:

  • To investigate the association between 5-HTTLPR polymorphism (short and long alleles) and attention bias in emotional processing.
  • To explore how top-down processing of emotions is affected by 5-HTTLPR variation.

Main Methods:

  • Genotyping for 5-HTTLPR polymorphism in 162 healthy participants.
  • Administration of background interviews and psychological screening.
  • Performance evaluation using The Emo 1-back task with emotional facial stimuli.

Main Results:

  • Participants with the short 5-HTTLPR allele showed reduced accuracy in The Emo 1-back task when viewing sad or fearful faces.
  • No significant difference in accuracy was observed for happy or neutral emotional faces.

Conclusions:

  • The 5-HTTLPR polymorphism in the serotonin transporter gene is associated with altered emotion processing.
  • Specific allelic variations may influence attention bias towards negative emotional stimuli.