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Infective endocarditis due to Enterobacter cloacae resistant to third- and fourth-generation cephalosporins

Yusuke Yoshino1, Shu Okugawa2, Satoshi Kimura1

  • 1Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8606, Japan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|September 29, 2012
PubMed

Insights

This case study shows long-term meropenem and amikacin effectively treated infective endocarditis caused by drug-resistant Enterobacter cloacae. This combination therapy offers a potential strategy for similar Gram-negative bacterial infections.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Infective endocarditis (IE) is a serious infection, often caused by bacteria.
  • Multi-drug resistant Gram-negative bacilli are emerging as challenging IE pathogens.
  • Enterobacter cloacae resistant to cephalosporins presents a significant treatment hurdle.

Observation:

  • A case of IE caused by multi-drug resistant Enterobacter cloacae was reported.
  • The patient was treated with a long-term combination of meropenem and amikacin.
  • This regimen targeted the cephalosporin-resistant Gram-negative bacteria.

Findings:

  • The combination therapy of meropenem and amikacin demonstrated successful treatment of IE.
  • This approach proved effective against a resistant strain of Enterobacter cloacae.
  • Long-term administration of beta-lactam and aminoglycoside was key.

Implications:

  • This therapeutic strategy may be applicable to future IE cases caused by similar pathogens.
  • It highlights the potential of combining beta-lactam and aminoglycoside antibiotics.
  • This offers a viable option for treating IE due to non-HACEK Gram-negative bacilli.
Keywords:
Cephalosporin resistantEnterobacter cloacaeInfective endocarditisManagement option

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