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Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

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Related Experiment Video

Updated: May 18, 2026

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro
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Adiponectin: a novel link between adipocytes and COPD.

Yoshito Takeda1, Kaori Nakanishi, Isao Tachibana

  • 1Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. yoshito@imed3.med.osaka-u.ac.jp

Vitamins and Hormones
|September 29, 2012
PubMed
Summary

Adiponectin (APN) plays a crucial role in lung health. Mice lacking APN develop a chronic obstructive pulmonary disease (COPD)-like condition, indicating APN’s importance in preventing lung disease and related issues.

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Published on: June 3, 2016

Area of Science:

  • Pulmonary Medicine and Adipokine Research
  • Investigating the role of adiponectin in respiratory diseases

Background:

  • Adiponectin (APN) is an adipokine with beneficial antiapoptotic, anti-inflammatory, and anti-oxidative properties.
  • Chronic obstructive pulmonary disease (COPD) is a major global health issue, often linked to smoking and associated with comorbidities like cardiovascular disease and osteoporosis.
  • The molecular links between COPD and its comorbidities are not well understood.

Purpose of the Study:

  • To review recent advancements in understanding the physiological and pathological roles of adiponectin within the lung.
  • To explore the connection between adiponectin deficiency and the development of COPD-like phenotypes and extrapulmonary effects.

Main Methods:

  • Review of existing scientific literature on adiponectin and its function in lung pathology.
  • Analysis of studies investigating the effects of adiponectin deficiency in animal models, specifically focusing on COPD development.

Main Results:

  • Mice lacking adiponectin (APN) spontaneously exhibit a chronic obstructive pulmonary disease (COPD)-like phenotype.
  • Adiponectin deficiency in mice leads to extrapulmonary effects, including systemic inflammation, weight loss, and osteoporosis.
  • These findings suggest a critical role for APN in lung pathology and highlight cross-talk between lung and adipose tissues.

Conclusions:

  • Adiponectin is vital for maintaining lung health and preventing the development of COPD.
  • The absence of APN contributes to both pulmonary and extrapulmonary complications associated with COPD.
  • This review underscores the significance of APN in the context of lung disease and its systemic implications.