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(Pro)renin receptor and vacuolar H(+)-ATPase
1Department of Medicine II, Endocrinology and Hypertension, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan. atzichi@endm.twmu.ac.jp
The Keio Journal of Medicine
|September 29, 2012
Summary
The (pro)renin receptor [(P)RR] modulates vacuolar H(+)-ATPase (V-ATPase) function and Wnt signaling. This review explores (P)RR
Area of Science:
- Biochemistry
- Cell Biology
- Physiology
Background:
- The (pro)renin receptor [(P)RR] binds prorenin and renin, activating them and mediating intracellular signaling.
- (P)RR is crucial in the tissue renin-angiotensin system, contributing to end-organ damage in hypertension and diabetes.
- A (P)RR fragment, ATP6AP2, associates with vacuolar H(+)-ATPase (V-ATPase), a proton pump vital for cellular functions.
Purpose of the Study:
- To review current understanding of (P)RR as a modulator of V-ATPase.
- To explore the novel function of (P)RR as an adaptor protein in Wnt signaling.
- To discuss future perspectives in translational research regarding (P)RR and V-ATPase.
Main Methods:
- Review of recent studies utilizing conditional knockout mice to investigate (P)RR function.
- Analysis of research demonstrating (P)RR's role as an adaptor protein.
- Synthesis of current literature on (P)RR's interaction with V-ATPase.
Main Results:
- (P)RR plays a significant role in V-ATPase function.
- (P)RR acts as an adaptor protein connecting the Wnt receptor complex and V-ATPase.
- (P)RR is a multi-functional molecule with complex structure and activity.
Conclusions:
- (P)RR is a key regulator of V-ATPase.
- Understanding (P)RR's role in V-ATPase and Wnt signaling offers therapeutic potential.
- Further translational research is warranted to explore (P)RR's clinical applications.
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