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Updated: May 18, 2026
09:35
Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
Published on: June 16, 2020
Prognostic implications of progressive cardiac conduction disease
Tamiro Kawaguchi1, Hideki Hayashi, Akashi Miyamoto
1Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan.
Circulation Journal : Official Journal of the Japanese Circulation Society
|September 29, 2012
Summary
Progressive cardiac conduction disease (PCCD) severity, indicated by increasing PR interval and QRS duration, significantly predicts heart failure hospitalization and cardiovascular death. This finding highlights the prognostic value of monitoring ECG changes in patients with PCCD.
Area of Science:
- Cardiology
- Electrocardiography
- Clinical Research
Background:
- Progressive cardiac conduction disease (PCCD) involves a worsening PR interval and QRS duration.
- The underlying pathophysiological mechanisms of PCCD are diverse.
- The association between PCCD progression and adverse cardiovascular outcomes requires further investigation.
Purpose of the Study:
- To determine if progressive cardiac conduction disease (PCCD) is linked to an increased risk of cardiovascular morbidity and mortality.
- To assess the prognostic value of temporal ECG changes in patients with PCCD.
Main Methods:
- Utilized digital analysis of 359,737 12-lead ECGs to identify patients with PCCD.
- Enrolled 458 patients with PCCD in a hospital-based cohort for long-term follow-up (mean 13.3 years).
- Employed multivariate Cox proportional hazards analysis to evaluate associations between ECG parameters and outcomes.
Main Results:
- A temporal increase in PR interval (≥ 2 ms/year) and QRS duration (≥ 3 ms/year) was significantly associated with heart failure hospitalization.
- Higher rates of PR interval increase (≥ 4 ms/year) and QRS duration increase (≥ 5 ms/year) were significantly linked to cardiovascular mortality.
- The study identified specific thresholds for ECG changes indicating increased risk.
Conclusions:
- The severity of progressive cardiac conduction disease (PCCD) is an independent predictor of heart failure hospitalization.
- Worsening PCCD is significantly associated with an increased risk of cardiovascular mortality.
- Monitoring the rate of change in PR interval and QRS duration on ECG is crucial for risk stratification in PCCD patients.
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