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Performing Behavioral Tasks in Subjects with Intracranial Electrodes
Published on: October 2, 2014
Cognitive and behavioral functioning in 82 patients with trigonocephaly
Joris J B van der Vlugt1, Jacques J N M van der Meulen, Hanneke E Creemers
1Rotterdam and Amsterdam, The Netherlands From the Departments of Plastic and Reconstructive Surgery and Child and Adolescent Psychiatry, Sophia Children&s Hospital/Erasmus Medical University Center, and the Faculty of Behavioral and Social Sciences, University of Amsterdam.
Behavioral problems in trigonocephaly patients are primarily linked to lower intelligence, not extracranial anomalies. This study assessed ADHD, ODD, conduct disorder, and autism spectrum features in trigonocephaly patients.
Area of Science:
- Neuroscience
- Developmental Pediatrics
- Genetics
Background:
- Trigonocephaly, a skull malformation, is associated with potential cognitive and behavioral issues.
- Previous research has not fully elucidated the interplay between trigonocephaly, intelligence, and specific psychiatric disorders.
Purpose of the Study:
- To determine the prevalence of attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), conduct disorder (CD), and autism spectrum disorder (ASD) features in trigonocephaly patients.
- To investigate the association between extracranial anomalies and cognitive/behavioral problems in this population, controlling for IQ.
Main Methods:
- 82 patients aged 4-18 with trigonocephaly were evaluated.
- Validated instruments, including the Social Communication Questionnaire and the Diagnostic Interview Schedule for Children-Parent Version, were used.
- Clinical assessment identified extracranial anomalies.
Main Results:
- 9% of patients had mental retardation (IQ <70).
- Psychopathology prevalence was 70% in patients with IQ <85 versus 24% in those with IQ ≥85.
- Extracranial anomalies correlated with lower IQ but not increased behavioral problems when IQ was controlled.
Conclusions:
- The high rate of behavioral problems in trigonocephaly is largely explained by co-occurring low intelligence.
- Cognitive assessment is crucial when evaluating behavioral concerns in trigonocephaly patients.
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