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Updated: May 18, 2026

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Published on: February 25, 2022
Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape
I Larrabide1, M L Aguilar, H G Morales
1Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine, Barcelona, Spain. ignacio.larrabide@upf.edu
Flow diverters significantly alter blood flow dynamics within aneurysms, impacting thrombosis. Pressure changes play a minor role, while altered wall shear stress and velocity are key to thrombus formation, especially in smaller or fusiform aneurysms.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Computational Fluid Dynamics
Background:
- Flow diverters (FDs) are used to treat aneurysms, often leading to thrombosis and remodeling.
- Understanding the influence of intra-aneurysmal pressure and aneurysm morphology is crucial.
Purpose of the Study:
- To investigate the role of hemodynamic changes, particularly intra-aneurysmal pressure, after flow diverter implantation.
- To analyze the impact of aneurysm size and shape on hemodynamic variables post-FD placement.
Main Methods:
- Computational fluid dynamics (CFD) simulations were performed on 23 internal carotid artery aneurysms.
- Hemodynamic variables including wall shear stress (WSS), velocity, and pressure were assessed before and after virtual FD implantation.
Main Results:
- Most hemodynamic variables, except mean intra-aneurysmal pressure, significantly decreased post-FD placement (P<.01).
- While minimum/maximum pressures changed slightly, the changes were not clinically relevant.
- Reduced WSS and velocity were more pronounced in smaller aneurysms and fusiform compared to saccular shapes.
Conclusions:
- Intra-aneurysmal pressure changes have a minimal role in secondary ruptures after FD use.
- Altered WSS and velocity are significant factors in intra-aneurysmal thrombus formation.
- Aneurysm size and shape influence the hemodynamic effects of flow diverters, impacting treatment outcomes.
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