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Updated: May 18, 2026
09:16
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
Published on: June 3, 2018
Cardiovascular disease: primary prevention, disease modulation and regenerative therapy
1Department of Vascular and Endovascular Surgery, Western Vascular Institute, University College Hospital Galway, Ireland. sherif.sultan@hse.ie
Vascular
|September 29, 2012
Summary
Harnessing nutrient-gene interactions can accelerate cardiovascular repair and optimize mitochondrial function for disease prevention. This approach complements conventional treatments and enhances quality of life.
Area of Science:
- Functional metabolic vascular medicine
- Nutrigenomics and cardiovascular health
- Regenerative medicine and primary prevention
Background:
- Cardiovascular primary prevention and regeneration are key areas in metabolic vascular medicine.
- Nutrient-gene interaction offers a novel approach to modulate cellular processes.
- Conventional treatments may have adverse effects on metabolic pathways crucial for cardiovascular health.
Purpose of the Study:
- To review and harmonize cardiovascular regenerative medicine, nutrigenomics, and primary prevention.
- To investigate the role of nutrient-gene interactions in cardiovascular repair and mitochondrial function.
- To analyze adverse effects of pharmacotherapies on metabolic pathways relevant to cardiovascular regeneration.
Main Methods:
- Comprehensive literature review of PubMed, EMBASE, and Cochrane databases.
- Focused search on randomized controlled trials of cardiovascular pharmacotherapies.
- Analysis of metabolic pathways including nitric oxide and glucose metabolism.
Main Results:
- Low sugar and low insulin levels are consistent findings in cardiovascular-free centenarians.
- Aging is associated with increased insulin levels, impacting cardiovascular rejuvenation.
- Nutrient-gene interaction through specific nutrients can accelerate cell repair and optimize mitochondrial function.
Conclusions:
- Cardiovascular regenerative programs, guided by nutrigenomics, offer a promising approach.
- Primary prevention strategies are essential for improved cardiovascular outcomes.
- This novel science complements conventional endovascular practices, enhancing efficacy and quality of life.
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