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[Experimental study on anaphylactoid reactions induced by shengmai injection (new production process) on Cynomolgus
Fengjie Li1, Ping He, Renmao Tang
1Experimental Research Center of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. lfj1210@126.com
Objective:
To compare the anaphylactoid effect of old Shengmai injection and new Shengmai injection on Cynomolgus monkey.
Method:
Cynomolgus monkeys were randomly divided into 4 groups, and were respectively injected with 5% glucose injection, old Shengmai injection, new Shengmai injection, positive control drug. The changes of each monkey were observed from injection before until 24 hours after injection, and the response level was determined according to the severity of the symptoms. Blood samples were collected before injection and at 10 min after injection for measuring histamine content in plasma. Blood pressure and heart rates were detected before injection and at 10 min after injection. Sensitization of the injection was comprehensively determined by combined the response level of symptoms and the histamine level.
Result:
The Cynomolgus monkeys administrated with old Shengmai injection showed typical symptoms of anaphylactoid reactions and the content of serum histamine is not more than doubled. The Cynomolgus monkeys administrated with new Shengmai injection showed untypical symptoms of anaphylactoid reactions and the content of serum histamine did not rise.
Conclusion:
The old Shengmai injection can induce typical anaphylactoid reactions on Cynomolgus monkeys, and the sensitization ability is strong. The symptoms of anaphylactoid reactions induced by the new Shengmai injection appeared later and showed lesser degree with the sensitization lower.