Digital clubbing due to secondary hyperparathyroidism

Five patients in our dialysis population had digital changes suggestive of clubbing in association with severe secondary hyperparathyroidism. All had parathyroidectomies between June 1986 and December 1987. They represented 0.6% of the patients in our dialysis population and 17.8% of our patients who required operative management of secondary hyperparathyroidism. The clubbing was occasionally painful, and the digits were tender in response to palpation. Parathyroidectomy yielded excessive amounts of hyperplastic parathyroid tissue in each case. Postoperatively, the symptoms were relieved, when present, and the digital changes were stabilized. We believe that these findings are associated with severe secondary hyperparathyroidism and should be looked for in dialysis patients with renal osteodystrophy.