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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Updated: May 18, 2026

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

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Published on: March 8, 2018

Antibody-linked spherical nucleic acids for cellular targeting.

Ke Zhang1, Liangliang Hao, Sarah J Hurst

  • 1Department of Chemistry and the International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.

Journal of the American Chemical Society
|October 2, 2012
PubMed
Summary
This summary is machine-generated.

Researchers developed targeted spherical nucleic acid (SNA) constructs for precise gene regulation. These antibody-functionalized SNAs show enhanced cellular uptake and gene knockdown in specific cells, improving selectivity for gene therapy applications.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Nanotechnology

Background:

  • Spherical nucleic acid (SNA) constructs are potent gene regulation agents.
  • Current SNA constructs lack cellular selectivity, limiting their therapeutic applications.

Purpose of the Study:

  • To develop targeted SNA constructs with improved cellular selectivity.
  • To functionalize SNAs with antibodies for specific antigen targeting.

Main Methods:

  • Noncovalent functionalization of SNA constructs with antibody-DNA conjugates.
  • Design and synthesis of HER2-targeting SNAs.
  • Evaluation of cellular uptake and gene knockdown efficiency in target and off-target cells.

Main Results:

  • HER2-targeting SNAs demonstrated selective cellular uptake.
  • Significantly enhanced gene knockdown was observed in cells overexpressing HER2.
  • Targeted SNAs showed improved specificity compared to antibody-free controls.

Conclusions:

  • Antibody-mediated targeting enhances the cellular selectivity of SNA constructs.
  • Targeted SNAs offer a promising strategy for selective gene regulation and potential therapeutic interventions.
  • This approach advances the development of precision nanomedicine for gene therapy.