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The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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Related Experiment Video

Updated: May 18, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

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Published on: January 17, 2018

Ectopic pyriform sinus parathyroid adenoma.

N Guevara1, B Agopian, D Benisvy

  • 1Institut universitaire de la face et du cou, groupement de coopération Sanitaire, centre hospitalier universitaire de Nice, centre Antoine-Lacassagne,31, avenue de Valombrose, 06107 Nice cedex 2, France. guevara.n@chu-nice.fr

European Annals of Otorhinolaryngology, Head and Neck Diseases
|October 2, 2012
PubMed
Summary

Ectopic parathyroid adenomas in the pyriform sinus are rare. Technetium-99m sestamibi SPECT/CT aids diagnosis, and endoscopic CO2 laser resection is the preferred treatment for this challenging condition.

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Area of Science:

  • Endocrinology
  • Head and Neck Surgery
  • Nuclear Medicine

Background:

  • Persistent primary hyperparathyroidism can result from ectopic parathyroid adenomas.
  • Previous failed cervical exploration complicates the diagnosis and treatment of recurrent hyperparathyroidism.

Observation:

  • A 44-year-old woman presented with persistent primary hyperparathyroidism post-surgery.
  • Computed tomography and technetium-99m sestamibi SPECT/CT indicated an ectopic parathyroid adenoma in the pyriform sinus.

Findings:

  • Histopathology confirmed a parathyroid adenoma in the pyriform sinus.
  • Endoscopic CO2 laser resection successfully removed the submucosal tumor.

Implications:

  • Pyriform sinus is a rare location for parathyroid adenomas.
  • Technetium-99m sestamibi SPECT/CT is crucial for diagnosing ectopic adenomas, particularly after failed neck surgery.
  • Endoscopic CO2 laser resection offers an effective treatment for pyriform sinus parathyroid adenomas.