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Updated: May 18, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
Paranasal sinus rhabdomyosarcoma: a rare tumor of poor prognosis
A El Sanharawi1, B Coulibaly, J-P Bessede
1Service d'oto-rhinolaryngologie et chirurgie cervico-faciale, CHU de Limoges, 2, avenue Martin-Luther-King, 87000 Limoges, France.
Introduction:
Rhabdomyosarcoma (RMS) is a rare sarcoma, in which paranasal sinus locations are exceptional in adults.
Case Report:
We report a case of ethmoid metastatic RMS in a 48-year-old patient, discovered in connection with recurrent epistaxis associated with exophthalmia and ophthalmoplegia. The tumor was inoperable and chemotherapy based on adriamycin was initiated. The course was, however, marked by rapid worsening of symptoms and the patient's death.
Discussion:
Paranasal sinus RMS shows no specific clinical signs, and diagnosis is mainly based on immunohistochemical analysis. The association of surgery and chemo-radiotherapy is the optimal attitude, but surgical resection is often impossible due to local extension. Prognosis in adults is poor.
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